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5 Recommended Articles from PLOS Biology Associate Editor Paula Jauregui

Our staff editors continue to share recent exciting, interesting, and thought-provoking PLOS Biology reads in this recommended articles series. This week, Associate Editor Paula Jauregui shares 5 picks for the PLOS Biology community.

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

From the Abstract:

“Altogether, our SARS-CoV-2 toolkit, which can be directly accessed via our website at, constitutes a resource with considerable potential to advance COVID-19 vaccine design, drug testing, and discovery science (…)”

Nonsense-mediated decay controls the reactivation of the oncogenic herpesviruses EBV and KSHV

From the Abstract:

“In conclusion, our results identify NMD as an important host process that controls oncogenic herpesvirus reactivation, which may be targeted for the therapeutic induction of lytic reactivation and the eradication of tumor cells (…)”

Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart

From the Abstract:

“The molecular changes associated with the response to Borrelia burgdorferi over the course of infection are poorly understood. Here, we identify broad transcriptomic and proteomic changes in the heart during infection that reveal a profound down-regulation of mitochondrial components (…)”

Cell cycle-dependent and independent mating blocks ensure fungal zygote survival and ploidy maintenance

From the Abstract:

“Using long-term imaging and flow-cytometry approaches, we identify previously unrecognized and independent roles for Mei3 and Mei2 in zygotes (…)”

Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis–infected lungs

From the Abstract:

“Here, we developed correlative light, electron, and ion microscopy in tissue (CLEIMiT) and used it to identify the cell type–specific accumulation of an antibiotic in lung lesions of mice infected with Mycobacterium tuberculosis(…)”

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